Rachael W. Sirianni

The ultrastructure of subarachnoid trabeculae in non-human primates varies by tissue region within the central nervous system

This study examines ultrastructural variations in subarachnoid trabeculae across different CNS regions in non-human primates using SEM and fixation techniques.

Ang2 and TAT targeting of leptomeningeal disease by the intravenous and intrathecal routes: a comparative analysis

This study compares the targeting efficiency of Ang2 and TAT peptides via intravenous and intrathecal routes in leptomeningeal disease models, finding TAT achieves better targeting in specific regions.

Solvent-free Nanoparticle Assembly Protocol (SNAP): one-pot formulation of drug loaded polyester nanoparticles and their vessel size-dependent perivascular transport

This paper introduces a solvent-free nanoparticle formulation method (SNAP) that rapidly produces stable drug-loaded polyester nanoparticles and demonstrates their vessel size-dependent perivascular transport in vivo.

Intrathecal infusion of hypertonic fluid enables CSF Flow Enhancement (CFE) to facilitate nanoparticle delivery to the brain and spinal cord

This study demonstrates that intrathecal infusion of hypertonic fluid enhances cerebrospinal fluid flow, significantly improving nanoparticle delivery to the central nervous system.

Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route

This study develops a nanoparticle system to deliver Panobinostat intrathecally for treating metastatic medulloblastoma, showing improved drug distribution and survival benefits in mice.

Differential sex-dependent responses of circulating steroid hormones and cortical gene expression in a preclinical traumatic brain injury model

This study examines sex-dependent changes in circulating steroid hormones and cortical gene expression following traumatic brain injury in mice, revealing sex-specific alterations in hormone levels and gene expression related to immune and tissue responses.