Loss of the Y chromosome drives cancer metabolic reprogramming
Boopathi Subramaniyan, Bipul R. Acharya, Prince Anand, Saravana Kumar Kailasam Mani, Saswat Mohapatra, Xingyu Chen, Fangyuan Qu, Yesai S. Fstkchyan, Corazon Gutierrez, Hany A. Abdel-Hafiz, James C. Costello, Dan Theodorescu
The paper shows that loss of the Y chromosome in bladder cancer drives metabolic reprogramming through DDR2, enhancing glycolysis and tumor aggressiveness.
bioRxiv · Aug 26, 2025 · PreprintCancer Biology