Yesai S. Fstkchyan

This study develops iPSC-derived prostate organoids with and without BRCA2 mutations, showing tumorigenic changes and cancer markers in mutated organoids.

The paper shows that loss of the Y chromosome in bladder cancer drives metabolic reprogramming through DDR2, enhancing glycolysis and tumor aggressiveness.

This paper describes a method to efficiently generate definitive hemogenic endothelium from human pluripotent stem cells, which can differentiate into hematopoietic progenitors and stem cells with multilineage potential.