Dan Theodorescu

This study develops iPSC-derived prostate organoids with and without BRCA2 mutations, showing tumorigenic changes and cancer markers in mutated organoids.

The paper shows that loss of the Y chromosome in bladder cancer drives metabolic reprogramming through DDR2, enhancing glycolysis and tumor aggressiveness.

This study identifies molecular changes in bladder mucosa that initiate cancer, revealing inflammation's role and mutation patterns linked to early carcinogenesis.