Rescue of Auditory Function by a Single Administration of AAV-TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8
Wan Du, Volkan Ergin, Corena Loeb, Mingqian Huang, Stewart Silver, Ariel Miura Armstrong, Zaohua Huang, Channabasavaiah B. Gurumurthy, Hinrich Staecker, Xue Zhong Liu, Zheng‐Yi Chen
This study shows that a single AAV2-hTMPRSS3 injection rescues auditory function in aged mice with DFNB8 deafness, restoring it to wildtype levels.
Molecular Therapy · May 26, 2023Peer-reviewedNeuroscience