Zheng‐Yi Chen

This study evaluates the efficacy and safety of AAV1-hOTOF gene therapy in mice and non-human primates for treating DFNB9 hearing loss.

This study shows that a single AAV2-hTMPRSS3 injection rescues auditory function in aged mice with DFNB8 deafness, restoring it to wildtype levels.

This study identifies TMEM43 mutations as a cause of autosomal dominant auditory neuropathy spectrum disorder by showing their interaction with Connexin-mediated channels in cochlear glia-like supporting cells.

This study shows that skipping exon 13 of the USH2A gene produces functional Usherin protein in mice, supporting exon-skipping as a therapeutic approach for USH2A-related diseases.