Channabasavaiah B. Gurumurthy

SYNAPTOTAGMIN-9 IN MOUSE RETINA

This study investigates the role of Synaptotagmin-9 in the mouse retina, showing its involvement in regulating cone signal transmission through rod cells.

Rescue of Auditory Function by a Single Administration of AAV-TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8

This study shows that a single AAV2-hTMPRSS3 injection rescues auditory function in aged mice with DFNB8 deafness, restoring it to wildtype levels.

Delivering mRNAs to mouse tissues using the SEND system

This study demonstrates the SEND process in vivo using genetically engineered mouse models, showing potential for using SEND-VLPs as a gene therapy tool for delivering mRNAs to tissues.

Structure of long-range direct and indirect spinocerebellar pathways as well as local spinal circuits mediating proprioception.

The paper defines the anatomical structure of long-range and local proprioceptive circuits in mice, revealing distinct pathways and their functional implications.

Slc26a9P2ACre, a new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia

The paper introduces a new pan-otic CRE driver, Slc26a9P2ACre, which shows reduced brain activity and is used to study FGF signaling and hearing loss.

Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I

This study uses CRISPR/Cas9 to edit hematopoietic stem cells to express iduronidase, correcting Mucopolysaccharidosis type I in mice.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

A transgenic pig model expressing a ZsGreen1 reporter across an extensive array of tissues

This study quantifies CMV promoter activity in various porcine tissues using a transgenic pig model expressing ZsGreen1, revealing tissue-specific expression patterns.

Reprogramming human T cell function and specificity with non-viral genome targeting

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.

In situ genome editing method suitable for routine generation of germline modified animal models

This paper improves the GONAD method for in situ genome editing, achieving efficiency comparable to microinjection for generating germline modified animal models.

An Efficient CRISPR Protocol For Generating Conditional And Knock-In Mice Using Long Single-Stranded DNA Donors

This paper introduces an efficient CRISPR protocol using long single-stranded DNA donors to generate conditional and knock-in mice with higher success rates than existing methods.