Author

Xue Zhong Liu

University of MiamiORCID 0000-0002-4758-6470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Ahmad N. Abou TayouniD· 2 shared Andrea M. OzaiD· 2 shared Andrew R. GrantiD· 2 shared Anne B. Skvorak GierschiD· 2 shared Arti PandyaiD· 2 shared Cynthia Casson MortoniD· 2 shared Hatice DuzkaleiD· 2 shared Heidi L. RehmiD· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Ahmad N. Abou TayounORCID

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Author profile →

4 papers

Recent·Most cited

Rescue of Auditory Function by a Single Administration of AAV-TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8

Wan Du, Volkan Ergin, Corena Loeb, Mingqian Huang, Stewart Silver, Ariel Miura Armstrong, Zaohua Huang, Channabasavaiah B. Gurumurthy, Hinrich Staecker, Xue Zhong Liu, Zheng‐Yi Chen

This study shows that a single AAV2-hTMPRSS3 injection rescues auditory function in aged mice with DFNB8 deafness, restoring it to wildtype levels.

Molecular Therapy · May 26, 2023Peer-reviewedNeuroscience

Transcription Co-Factor LBH Is Necessary for Maintenance of Stereocilia Bundles and Survival of Cochlear Hair Cells

Huizhan Liu, Kimberlee P. Giffen, M’hamed Grati, Seth W. Morrill, Yi Li, Xue-Zhong Liu, Karoline J. Briegel, David Z. Z. He

This study shows that LBH is essential for maintaining cochlear hair cells and stereocilia bundles, with its loss causing progressive hearing loss and OHC degeneration.

bioRxiv · May 13, 2020 · PreprintNeuroscience

Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

Jun Shen, Andrea M. Oza, Ignacio del Castillo, Hatice Duzkale, Tatsuo Matsunaga, Arti Pandya, Hyunseok Peter Kang, Rebecca Mar‐Heyming, Saurav Guha, Krista Moyer, Christine Lo, Margaret A. Kenna, John J. Alexander, Yan Zhang, Yoel Hirsch, , Lisa A. Schimmenti

The paper resolves the classification of two GJB2 variants as pathogenic for autosomal recessive nonsyndromic hearing loss through expert consensus.

Genetics in Medicine · Jun 3, 2019Peer-reviewedGenetics

ClinGen Expert Clinical Validity Curation of 164 Hearing Loss Gene-Disease Pairs

Marina T. DiStefano, Sarah E. Hemphill, Andrea M. Oza, Rebecca K. Siegert, Andrew R. Grant, Madeline Y. Hughes, Brandon J. Cushman, Héla Azaiez, Kevin T. A. Booth, Alex Chapin, Hatice Duzkale, Tatsuo Matsunaga, Jun Shen, Wenying Zhang, Margaret A. Kenna, , Keijan Zhang

The paper curates 164 gene-disease pairs for hearing loss, classifying their clinical validity to improve genetic testing accuracy.

Genetics in Medicine · Mar 20, 2019Peer-reviewedGenomics