Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer disease models
Isabel H. Salas, Adrien Paumier, Tao Tao, Aksinya Derevyanko, Corey Switzler, Jillybeth Burgado, Melia Movsesian, Setareh Metanat, Trinity Dawoodtabar, Quinn N. Asbell, Arash Fassihi, Nicola J. Allen
The paper identifies glypican 5 downregulation in astrocytes as a contributor to synaptic dysfunction in Alzheimer's disease models and shows its reversal can improve cognitive function.
bioRxiv · Oct 30, 2024 · PreprintNeuroscience