Author

Setareh Metanat

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Nicola J. AlleniD· 2 shared Adrien PaumieriD· 1 shared Aksinya DerevyankoiD· 1 shared Arash FassihiiD· 1 shared Ayesha ThanawallaiD· 1 shared Brent Y. ChickiD· 1 shared Corey Switzler· 1 shared Diana C. HargreavesiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Nicola J. AllenORCID

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2 papers

Recent·Most cited

The antiviral Interferon pathway drives astrocyte aging and motor decline

Lara Labarta-Bajo, Ayesha Thanawalla, Irene L Gutierrez, Su May Lei Soe, Brent Y. Chick, Ioanna Andritsogianni, Setareh Metanat, Diana C. Hargreaves, Susan M. Kaech, Eiman Azim, Nicola J. Allen

This study shows that antiviral type I interferons drive astrocyte aging and motor decline in aging, with implications for therapeutic intervention.

bioRxiv · Nov 12, 2025 · PreprintNeuroscience

Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer disease models

Isabel H. Salas, Adrien Paumier, Tao Tao, Aksinya Derevyanko, Corey Switzler, Jillybeth Burgado, Melia Movsesian, Setareh Metanat, Trinity Dawoodtabar, Quinn N. Asbell, Arash Fassihi, Nicola J. Allen

The paper identifies glypican 5 downregulation in astrocytes as a contributor to synaptic dysfunction in Alzheimer's disease models and shows its reversal can improve cognitive function.

bioRxiv · Oct 30, 2024 · PreprintNeuroscience