Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes fate in chronic liver disease
Rita Manco, Camilla Moliterni, Gauthier Neirynck, Rachel Claus, Maxime De Rudder, Corinne Picalausa, Leana Ducor, Montserrat Fraga, Laurent Coubeau, Alice Dongier, Pamela Baldin, Frédéric P. Lemaigre, Christine Sempoux, Alexandra Dili, Isabelle Anne Leclercq
The paper identifies laminin and liver sinusoidal endothelial cells as key regulators of cholangiocyte fate in chronic liver disease, showing that preventing LSEC capillarization enhances DR differentiation into hepatocytes.
Journal of Hepatology · Mar 27, 2026Peer-reviewedCell Biology