Frédéric P. Lemaigre

This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.

The paper identifies laminin and liver sinusoidal endothelial cells as key regulators of cholangiocyte fate in chronic liver disease, showing that preventing LSEC capillarization enhances DR differentiation into hepatocytes.

This study uses spatial transcriptomics to analyze two gallbladder cancer patients, showing distinct progression paths and the role of SEMA4A repression in tumor development.

The paper models how Let-7 couples cell cycle and transformation gene regulatory networks, showing their mutual control and role in cancer progression and tumor heterogeneity.