Christine L Sempoux

Actionable spatial prostanoid barriers constrain BiTE-driven adoptive T cell immunity in intact human tumors

The paper uses patient-derived explants to study BiTE-driven T cell responses in tumors, identifying the COX/PGE2 axis as a barrier to immune activation and showing COX inhibition enhances anti-tumor effects.

Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes fate in chronic liver disease

The paper identifies laminin and liver sinusoidal endothelial cells as key regulators of cholangiocyte fate in chronic liver disease, showing that preventing LSEC capillarization enhances DR differentiation into hepatocytes.

Spatial transcriptomics profiling of gallbladder adenocarcinoma: a detailed two-case study of progression from precursor lesions to cancer

This study uses spatial transcriptomics to analyze two gallbladder cancer patients, showing distinct progression paths and the role of SEMA4A repression in tumor development.

In vivo reprogramming leads to premature death due to hepatic and intestinal failure.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.