Author

Isabelle Anne Leclercq

UCLouvainORCID 0000-0001-7934-6693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Chantal DessyiD· 2 shared Hrag Esfahani· 2 shared Justine Lallement· 2 shared Sébastian BottiD· 2 shared Alexandra DiliiD· 1 shared Alice DongieriD· 1 shared Alice MarinoiD· 1 shared Camilla MoliterniiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

Chantal DessyORCID

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3 papers

Recent·Most cited

Cell BiologyJournal of HepatologyPeer-reviewedMar 27, 2026

Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes fate in chronic liver disease

Rita Manco, Camilla Moliterni, Gauthier Neirynck…·Isabelle Anne Leclercq

The paper identifies laminin and liver sinusoidal endothelial cells as key regulators of cholangiocyte fate in chronic liver disease, showing that preventing LSEC capillarization enhances DR differentiation into hepatocytes.

2 citationstop 5%

humanexperimental assay

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PhysiologybioRxivPreprintJun 10, 2025

Hepatic ADMA/PRMT1 axis regulation is associated with NO-dependent endothelial dysfunction in MASH

Justine Lallement, Sébastian Bott, Hrag Esfahani…·Chantal Dessy

This study investigates how MASH impairs endothelial function via NO-dependent mechanisms and identifies ADMA as a key liver-derived mediator.

DOI 10.1101/2025.06.10.658894

mouseproteomics

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PhysiologyClinical SciencePeer-reviewedAug 29, 2024

When the liver is in poor condition, so is the heart - cardiac remodelling in MASH mouse models

Sébastian Bott, Justine Lallement, Alice Marino…·Isabelle Anne Leclercq

This study examines cardiac remodelling in MASH mouse models, finding adverse structural changes in the heart linked to liver disease, not overfeeding or aging.

9 citations

mouseexperimental assay

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