Tissue-adapted NK cells shape pathogenic cDC1 niches in early arthritis
O Knight, Chiara Giordano, Anne Sae Lim von Stuckrad, Cornelia Winning, Chrissy Bolton, Christopher B. Mahony, Mir‐Farzin Mashreghi, Adam P. Croft, Tilmann Kallinich, Timo Rückert, Chiara Romagnani
The paper identifies NK cells as key orchestrators of adaptive immune niches in early arthritis by upregulating XCL1, which recruits XCR1+ cDC1s, forming pathogenic modules that correlate with disease severity.
bioRxiv · May 29, 2026 · PreprintImmunology