Mir‐Farzin Mashreghi

TLR-mediated activation of synovial fibroblasts from osteoarthritis patients promotes chondrocyte dysfunction

This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.

Tissue-adapted NK cells shape pathogenic cDC1 niches in early arthritis

The paper identifies NK cells as key orchestrators of adaptive immune niches in early arthritis by upregulating XCL1, which recruits XCR1+ cDC1s, forming pathogenic modules that correlate with disease severity.

Clinical development of gene edited tacrolimus-resistant Treg (FKBP12KO-Treg) to enable simultaneous immunosuppression and support of immune regulation

This paper develops gene-edited tacrolimus-resistant Treg cells (FKBP12KO-Treg) for clinical use in transplant recipients, showing they maintain immunoregulatory function while resisting tacrolimus.

Heterogeneous signaling pathways are critical for the persistence of memory T cells in spleen and bone marrow

This study identifies tissue-specific signaling pathways critical for memory T cell persistence in spleen and bone marrow.

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

The paper examines T-bet expression stability in virus-specific Th1 cells during chronic infection, finding that quantitative differences persist and some cells retain Tfh-like features.

Seasonal transcriptional profiling of malaria parasites using a new single-cell atlas of a Malian Plasmodium falciparum isolate

This study uses single-cell RNA-seq to profile seasonal changes in Plasmodium falciparum parasites, showing older parasites circulate in the dry season and transcriptional changes in exported proteins affecting cytoadhesion.

D-lactate enhances inflammatory and cytotoxic functions of Th1 cells through stereospecific control of mitochondrial ROS

This study identifies D-lactate's stereospecific role in enhancing Th1 cell cytotoxicity and inflammation through mitochondrial ROS regulation.

Urinary single-cell sequencing captures intrarenal injury and repair processes in human acute kidney injury

This study uses urinary single-cell RNA sequencing to analyze injury and repair processes in acute kidney injury, identifying distinct cellular and molecular dynamics.

Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint

This study combines bulk and single-cell RNA-seq to identify chondrocyte gene expression in murine knee joints, finding 75 overlapping genes related to cartilage homeostasis and osteoarthritis.