The Limits of Sequence-Based Biosecurity Screening Tools in the Age of AI-Assisted Protein Design
Bruce J. Wittmann, Nicole E. Wheeler, Steven T. Murphy, Tom Mitchell, Brittany Rife Magalis, Bryan T. Gemler, Kevin Flyangolts, James Diggans, Adam J. Clore, Jacob Beal, Craig Bartling, Tessa Alexanian, Eric Horvitz
This study evaluates the effectiveness of biosecurity screening tools against AI-generated synthetic homologs of proteins of concern, finding some tools can detect fragments as short as 50 nucleotides.
Frontiers in Bioengineering and Biotechnology · Jul 13, 2026Peer-reviewedSynthetic Biology