Author
Twist Bioscience (United States)ORCID 0000-0003-3871-2380Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Bruce J. Wittmann, Nicole E. Wheeler, Steven T. Murphy…·Eric Horvitz
This study evaluates the effectiveness of biosecurity screening tools against AI-generated synthetic homologs of proteins of concern, finding some tools can detect fragments as short as 50 nucleotides.
Tessa Alexanian, Jacob Beal, Craig Bartling…·Nicole E. Wheeler
The paper develops a rubric to define sequences of concern by analyzing test sequences and refining categorization through stakeholder review, reducing disputed categorization by 44.3% for controlled viruses.
Svetlana P. Ikonomova, Bruce J. Wittmann, Fernanda Piorino…·Geoffrey J. Taghon
This study evaluates the risks of AI-driven protein design by testing synthetic homologs against biosecurity screening software.
Bruce J. Wittmann, Tessa Alexanian, Craig M. Bartling…·Eric Horvitz
The paper evaluates biosecurity screening tools for detecting AI-generated synthetic protein homologs and reports improved detection rates through patches.