Author

Adam J. Clore

Integrated DNA Technologies (United States)ORCID 0000-0002-0930-1497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Synthetic Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 4 Approach:statistical model· 4 Assay:DNA methylation· 2 Approach:benchmark study· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jacob BealiD· 5 shared Tom MitchelliD· 4 shared Bryan T. GemleriD· 3 shared James DiggansiD· 3 shared Kevin FlyangoltsiD· 3 shared Nicole E. WheeleriD· 3 shared Steven T. MurphyiD· 3 shared Tessa AlexanianiD· 3 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersSynthetic Biology

Jacob BealORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Synthetic BiologyFrontiers in Bioengineering and BiotechnologyPeer-reviewedJul 13, 2026

The Limits of Sequence-Based Biosecurity Screening Tools in the Age of AI-Assisted Protein Design

Bruce J. Wittmann, Nicole E. Wheeler, Steven T. Murphy…·Eric Horvitz

This study evaluates the effectiveness of biosecurity screening tools against AI-generated synthetic homologs of proteins of concern, finding some tools can detect fragments as short as 50 nucleotides.

5 citationstop 1%

DNA methylationstatistical model

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BioinformaticsFrontiers in Bioengineering and BiotechnologyPeer-reviewedJun 4, 2026

Developing a Standard Definition for Sequences of Concern

Tessa Alexanian, Jacob Beal, Craig Bartling…·Nicole E. Wheeler

The paper develops a rubric to define sequences of concern by analyzing test sequences and refining categorization through stakeholder review, reducing disputed categorization by 44.3% for controlled viruses.

3 citationstop 1%

DNA methylationwhole-genome sequencing

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Synthetic BiologybioRxivPreprintDec 2, 2024

Toward AI-Resilient Screening of Nucleic Acid Synthesis Orders: Process, Results, and Recommendations

Bruce J. Wittmann, Tessa Alexanian, Craig M. Bartling…·Eric Horvitz

The paper evaluates biosecurity screening tools for detecting AI-generated synthetic protein homologs and reports improved detection rates through patches.

6 citations

statistical modelbenchmark study

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BioinformaticsScientific ReportsPeer-reviewedApr 3, 2023

Studying Pathogens Degrades BLAST-based Pathogen Identification

Jacob Beal, Adam J. Clore, Jeff Manthey

The paper highlights limitations of BLAST-based pathogen identification and suggests moving to specialized biosecurity tools.

22 citations

statistical modelbenchmarking

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GeneticsbioRxivPreprintJan 31, 2020

Highly Distinguished Amino Acid Sequences of 2019-nCoV (Wuhan Coronavirus)

Jacob Beal, Tom Mitchell, Daniel Wyschogrod…·Adam J. Clore

The paper identifies unique amino acid sequences in 2019-nCoV that distinguish it from other Coronaviridae viruses.

4 citations

protein sequenceexperimental assay

𝕏 PostBluesky