Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjects
Diana C. West-Szymanski, Zhou Zhang, Xiaolong Cui, Krissana Kowitwanich, Lu Gao, Zifeng Deng, Urszula Dougherty, Craig Williams, Shannon Merkle, Matthew T. Moore, Chuan He, Marc Bissonnette, Wei Zhang
This study uses machine learning to identify 5-hydroxymethylation biomarkers in cell-free DNA that can detect occult colorectal cancer up to 36 months before diagnosis.
bioRxiv · Feb 25, 2024 · PreprintGenomics