Matthew T. Moore

A cholinergic spinal pathway for the adaptive control of breathing

This study identifies a spinal cholinergic pathway that enhances breathing by amplifying phrenic motor neuron output during hypercapnia.

A sustained Hox program delineates brainstem neurons essential for breathing

The paper identifies Hox5's role in organizing and specializing brainstem neurons critical for breathing, showing its necessity for respiratory function and survival.

Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjects

This study uses machine learning to identify 5-hydroxymethylation biomarkers in cell-free DNA that can detect occult colorectal cancer up to 36 months before diagnosis.

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window

This study shows that catenin signaling is essential for phrenic motor neuron development but not maintenance, affecting their topography, clustering, and axon/dendrite growth.

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

This study shows that coordinated cadherin activity in respiratory motor neurons and interneurons is essential for proper circuit connectivity and breathing function.