The crystal structure and localization of Trypanosoma brucei invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage
Aitor Casas-Sánchez, Samïrah Perally, Raghavendran Ramaswamy, Lee R. Haines, Clair Rose, Cristina Yunta, Marcela Aguilera-Flores, Michael J. Lehane, Igor C. Almeida, Martin J. Boulanger, Alvaro Acosta-Serrano
The paper identifies and characterizes a novel family of invariant surface proteins in the metacyclic stage of Trypanosoma brucei, suggesting a more permissive VSG coat structure that may aid vaccine development.
bioRxiv · Nov 26, 2018 · PreprintMicrobiology