RNA polymerase II dynamics and mRNA stability feedback determine mRNA scaling with cell size
Matthew P. Swaffer, Georgi K. Marinov, Huan Zheng, Lucas Fuentes Valenzuela, Crystal Yee Tsui, Andrew W. Jones, Jessica Greenwood, Anshul Bharat Kundaje, William James Greenleaf, Rodrigo Reyes‐Lamothe, Jan Marcel Skotheim
The paper identifies RNAPII as the limiting factor for transcription scaling with cell size in budding yeast and shows that mRNA stability feedback compensates for sub-linear transcription growth.
Cell · Nov 1, 2023Peer-reviewedMolecular Biology