Author

Lucas Fuentes Valenzuela

Stanford UniversityORCID 0009-0002-7403-3537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Organism:yeast· 3 Assay:DNA methylation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jan Marcel SkotheimiD· 3 shared Matthew P. SwafferiD· 2 shared Andrew W. JonesiD· 1 shared Anshul Bharat KundajeiD· 1 shared Corbin E. Mitchell· 1 shared Crystal Yee Tsui· 1 shared Georgi K. MarinoviD· 1 shared Huan Zheng· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

Jan Marcel SkotheimORCID

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3 papers

Recent·Most cited

A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription

Jacob Kim, Shicong Xie, Lucas Fuentes Valenzuela, Jordan Yupeng Xiao, Michael Charles Lanz, Xin Gao, Matthew P. Swaffer, Corbin E. Mitchell, Seth M. Rubin, Kurt M. Schmoller, Jan Marcel Skotheim

Cell Reports · Apr 22, 2026Peer-reviewedCell Biology

The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth

Lucas Fuentes Valenzuela, Paul François, Jan Marcel Skotheim

The paper confirms the Product neutrality function accurately predicts double mutant fitness in budding yeast and shows it emerges from mechanistic models of cell growth.

eLife · Sep 2, 2025Peer-reviewedSystems Biology

RNA polymerase II dynamics and mRNA stability feedback determine mRNA scaling with cell size

Matthew P. Swaffer, Georgi K. Marinov, Huan Zheng, Lucas Fuentes Valenzuela, Crystal Yee Tsui, Andrew W. Jones, Jessica Greenwood, Anshul Bharat Kundaje, William James Greenleaf, Rodrigo Reyes‐Lamothe, Jan Marcel Skotheim

The paper identifies RNAPII as the limiting factor for transcription scaling with cell size in budding yeast and shows that mRNA stability feedback compensates for sub-linear transcription growth.

Cell · Nov 1, 2023Peer-reviewedMolecular Biology