Rodrigo Reyes‐Lamothe

The paper shows that cell size affects SBF and Whi5 chromatin binding to regulate the Start transition in budding yeast by altering their copy-number ratio and chromatin affinity.

The paper identifies a gene regulatory function of the Rtf1-H2Bub1-H3K4me axis and Rpb1 CTD in controlling fungal drug tolerance by linking them to resistance against hydroxyurea and azole antifungals.

The paper identifies RNAPII as the limiting factor for transcription scaling with cell size in budding yeast and shows that mRNA stability feedback compensates for sub-linear transcription growth.

The paper uses single-molecule fluorescence microscopy to study replisome subunit dynamics in live yeast, showing long residence times and coordinated activity, redefining the replisome architecture.