Matthew P. Swaffer

Cell size-dependent mRNA transcription drives proteome remodeling

The paper shows that cell size affects mRNA concentrations, driving proteome changes through transcriptional regulation.

Retrograde signalling mediates cellular adaptation to mitochondrial DNA copy number alterations

This study shows that yeast cells adapt to changes in mitochondrial DNA copy number through retrograde signaling and protein dosage compensation, allowing robust growth despite mtDNA fluctuations.

A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription

Cell Size Modulates SBF and Whi5 Chromatin Binding to Regulate the Start of the Budding Yeast Cell Cycle

The paper shows that cell size affects SBF and Whi5 chromatin binding to regulate the Start transition in budding yeast by altering their copy-number ratio and chromatin affinity.

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast

The paper shows that intracellular diffusion in fission yeast increases with cell size, linked to changes in proteome composition and DNA-to-cytoplasm ratio.

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output

The paper shows that polyploidy in C. elegans intestine increases transcriptional output and supports biosynthesis by compensating for mRNA dilution through increased RNA Polymerase II loading.

RNA polymerase II dynamics and mRNA stability feedback determine mRNA scaling with cell size

The paper identifies RNAPII as the limiting factor for transcription scaling with cell size in budding yeast and shows that mRNA stability feedback compensates for sub-linear transcription growth.

Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome

This study maps 5-hydroxymethyluracil and chromatin accessibility in Breviolum minutum to explore their genomic distribution and functional roles.

Long-range single-molecule mapping of chromatin accessibility in eukaryotes

This paper introduces SMAC-seq, a method for long-range chromatin accessibility mapping in eukaryotes, and demonstrates its application in yeast.