Microbiome-Derived Metabolites Shape CD4⁺ T-Cell Differentiations and Immune Aging in Chronic HIV-1 Infection
Amanda Cabral da Silva, Luke Flantzer, Jaclyn Weinberg, Shuya Y. Kyu, Lisa P. Daley‐Bauer, Ana Carolina Santana, Aarthi Talla, Amber Lynn Rittgers, Sarah Welbourn, D Gordon, Jeffrey Alan Tomalka, Vincent C. Marconi, D. T. Jones, Souheil‐Antoine Younes
This study identifies microbiome-derived metabolites, particularly p-cresol sulfate, that alter CD4 T-cell metabolism and promote immune aging in HIV-1 infection.
bioRxiv · Jan 14, 2026 · PreprintSystems Biology