Jeffrey Alan Tomalka

Preexisting chronic infection skews the epigenetic landscape of subsequent memory CD8 T cell responses

The paper shows that preexisting chronic LCMV infection skews the epigenetic and phenotypic responses of subsequent memory CD8 T cells to Listeria infection.

Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control

This study shows that IL-6 restricts pre-thymic T cell lineage commitment in SIV-infected rhesus macaques, contributing to loss of viral control.

Clinical and Cross-Domain Validation of an LLM-Guided, Literature-Based Gene Prioritization Framework

The paper validates an LLM-guided gene prioritization framework for sepsis and tests its generalizability to obesity and infection using clinical and proteomic data.

Microbiome-Derived Metabolites Shape CD4⁺ T-Cell Differentiations and Immune Aging in Chronic HIV-1 Infection

This study identifies microbiome-derived metabolites, particularly p-cresol sulfate, that alter CD4 T-cell metabolism and promote immune aging in HIV-1 infection.

Innate antiviral readiness drives the expansion of protective T stem cell memory against influenza

This study identifies innate antiviral readiness as a key driver of TSCM cell expansion, showing its predictive value for viral clearance and vaccine design.

A combination TLR7/8 and RIG-I agonist adjuvant reverts asthmatic allergic sensitization and prevents aggravated influenza infection in OVA-sensitized mice.

This study shows that combining TLR7/8 and RIG-I agonists prevents allergic sensitization and reduces influenza severity in OVA-sensitized mice.