Parkinson's Paradox: Alpha-synuclein's Selective Strike on SNc Dopamine Neurons over VTA
Leah T. Phan, D Miller, Adithya Gopinath, Min Lin, D Gunther, K Kiel, S Quintin, D Borg, Zahra Hasanpour Segherlou, A Newman, Zachary A. Sorrentino, J Miller E, Jordan M. Seibold, B Hoh, Benoit I. Giasson, Habibeh Khoshbouei
This study shows that alpha-synuclein elevates firing rates and impairs homeostatic regulation in SNc dopamine neurons, but not VTA neurons, before neurodegeneration occurs.
npj Parkinson s Disease · Jul 11, 2025Peer-reviewedNeuroscience