Author

D. A. Boas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 8 Physiology· 2

Signature Assays, Organisms & Methods

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Assay:imaging· 9 Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Organism:mouse· 5 Organism:human· 3 Approach:microscopy & imaging analysis· 2 Research Focus:spatial domain detection· 2 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

D. D. Postnov· 3 shared J. Tang· 3 shared K. Kilic· 3 shared S. E. Erdener· 3 shared J. Giblin· 2 shared J. Jiang· 2 shared S. Kura· 2 shared S. Sunil· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBioengineering

D. D. Postnov

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10 papers

Recent·Most cited

Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system

B. Kim, S. Zilpelwar, E. J. Sie, F. Marsili, B. Zimmermann, D. A. Boas, X. Cheng

This paper develops a fiber-based speckle contrast optical spectroscopy (SCOS) system for measuring cerebral blood flow and brain function with improved signal-to-noise ratio compared to traditional DCS.

bioRxiv · Apr 8, 2023Bioengineering

High-throughput deep tissue two-photon microscopy at kilohertz frame rates

S. Xiao, J. Giblin, D. A. Boas, J. Mertz

This paper presents a method to enable kilohertz frame rates in two-photon microscopy for deep tissue imaging, demonstrating its application in mouse brain neurovascular dynamics.

bioRxiv · Oct 24, 2022 · PreprintBioengineering

Measuring Capillary Flow Dynamics using Interlaced Two-Photon Volumetric Scanning

J. Giblin, S.-W. Park, J. Jiang, K. Kilic, S. Kura, D. A. Boas, I. A. Chen

The paper introduces a custom two-photon system with Bessel beams and a novel scan pattern to measure capillary flow dynamics in 3D with high temporal resolution and fluorescent specificity.

bioRxiv · Sep 12, 2022Bioengineering

Decoding Attended Spatial Location during Complex Scene Analysis with fNIRS.

M. H. Ning, M. Yucel, D. A. Boas, A. V. Luhmann, K. Sen

This study shows fNIRS can decode attended spatial locations during complex scene analysis, with FEF playing a major role and performance above chance early after cue onset.

bioRxiv · Sep 6, 2022 · PreprintBioengineering

Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke

C. Staehr, J. T. Giblin, E. Gutierrez-Jimenez, H. Guldbrandsen, J. Tang, S. L. Sandow, D. A. Boas, V. V. Matchkov

This study shows that arterial occlusion in mice leads to pericyte constriction and microcirculatory failure in peri-ischemic brain regions, impairing neurovascular coupling after reperfusion.

bioRxiv · Aug 26, 2022Physiology

Targeted photothrombotic stroke leads to disruptions in neurovascular coupling

S. Sunil, J. Jiang, S. Shah, S. Kura, K. Kilic, S. E. Erdener, C. Ayata, A. Devor, D. A. Boas

This study investigates how photothrombotic stroke disrupts neurovascular coupling and shows that acute recovery of this coupling predicts sensorimotor function recovery.

bioRxiv · Jan 22, 2022 · PreprintPhysiology

Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue

C. J. Liu, W. Ammon, R. Jones, J. Nolan, R. Wang, S. Chang, M. P. Frosh, A. Yendiki, D. A. Boas, C. Magnain, B. Fischl, H. Wang

This study improves PS-OCT quantification in human brain tissue using refractive index matching, reducing noise and improving birefringence measurements in both white and gray matter.

bioRxiv · Sep 12, 2021Bioengineering

Guidelines for obtaining an absolute blood flow index with laser speckle contrast imaging

S. Sunil, S. Zilpelwar, D. A. Boas, D. D. Postnov

This paper provides guidelines for making reliable absolute blood flow index measurements using laser speckle contrast imaging by addressing calibration and measurement stability issues.

bioRxiv · Apr 2, 2021 · PreprintBioengineering

Functional ultrasound speckle decorrelation-based velocimetry of the brain

J. Tang, D. D. Postnov, K. Kilic, S. E. Erdener, B. Lee, T. L. Szabo, D. A. Boas

This paper develops a high-speed, contrast-free ultrasound velocimetry technique for quantifying blood flow velocity in rodent brains and validates it through simulations, phantoms, and in vivo experiments.

bioRxiv · Mar 31, 2020Bioengineering

Dynamic Laser Speckle Imaging

D. D. Postnov, J. Tang, S. E. Erdener, K. Kılıc, D. A. Boas

This paper introduces dynamic laser speckle imaging (DLSI) to quantitatively measure light scattering dynamics and demonstrates its application in cerebral blood flow imaging in mice.

bioRxiv · May 21, 2019Bioengineering