HIV-1 Nef and CycK:CDK13 antagonize SERINC5 for optimal viral infectivity
Q. Chai, S. Li, M. K. Collins, R. Li, I. Ahmad, S. F. Johnson, D. A. Frabutt, Z. Yang, X. Shen, L. Sun, J. Hu, J. F. Hultquist, B. M. Peterlin, Y.-H. Zheng
This study identifies CycK:CDK13 as a kinase complex that phosphorylates SERINC5 at S360, enhancing Nef-mediated downregulation and counteracting its antiviral activity.
bioRxiv · May 24, 2021Microbiology