J. F. Hultquist

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal

This paper shows that inhibiting the Super Elongation Complex (SEC) with KL-2 increases HIV-1 transcription and reactivates latent virus, especially when combined with other latency reversing agents.

Exploiting rodent cell blocks for intrinsic resistance to HIV-1 gene expression in human T cells

This paper edits human T cells to mimic rodent host factors, creating resistance to HIV-1 and related lentiviruses by disrupting key viral protein interactions.

Contribution of 6mer seed toxicity to HIV-1 induced cytopathicity

This paper identifies HIV-encoded miRNA HIV-miR-TAR-3p as a cytotoxic factor that induces cell death via DISE through a noncanonical 6mer seed, revealing a mechanism for HIV-induced cytopathicity.

Rab11-FIP1C is dispensable for HIV-1 replication in primary CD4+ T cells but its role is cell-type-dependent in immortalized human T-cell lines

This study shows FIP1C is not essential for HIV-1 replication in primary CD4+ T cells but has cell-type-dependent effects in T-cell lines.

Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells

This paper develops methods to engineer extracellular vesicles for targeted delivery of biologics to T cells, demonstrating efficient cargo delivery using Cas9-sgRNA complexes.

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

This paper uses immunoPET to track SARS-CoV-2 infection in rhesus macaques, revealing infection of the male genital tract and differences in lung pathology between SARS-CoV-2 variants.

Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection

This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.

ICER controls HIV-1 infection and replication in elite controllers

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

HIV-1 Nef and CycK:CDK13 antagonize SERINC5 for optimal viral infectivity

This study identifies CycK:CDK13 as a kinase complex that phosphorylates SERINC5 at S360, enhancing Nef-mediated downregulation and counteracting its antiviral activity.

The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir

This study shows that CCL2 chemokine promotes early HIV reservoir formation by recruiting CCR2/5+ CD4 T cells to sites of inflammation during acute infection.

TRIM5α restriction of HIV-1-N74D viruses in lymphocytes is caused by a loss of cyclophilin A protection

This study shows that HIV-1-N74D viruses lose infectivity in CD4+ T cells due to reduced protection from cyclophilin A against TRIM5hu restriction.

Functional Landscape of SARS-CoV-2 Cellular Restriction

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5alpha Binding to the viral Core