High-Risk Human Papillomavirus Oncogenes Disrupt the Fanconi Anemia DNA repair Pathway by Impairing Localization and De-ubiquitination of FancD2
This paper shows that HPV oncogenes E6/E7 disrupt the FA DNA repair pathway by impairing FancD2 localization, de-ubiquitination, and downstream protein recruitment, increasing cisplatin sensitivity.
bioRxiv · Oct 30, 2018Cancer Biology