S. Khanal

Pyruvate Oxidation Sustains B Cell Antigen-Specific Activation to Exacerbate MASH

This study shows that B cell pyruvate oxidation supports antigen-specific activation, driving inflammation and fibrosis in MASH.

Characterization of Differences of Seed Endophytic Microbiome in Conventional and Organic Rice by Amplicon-based Sequencing and Culturing Methods

This study compares the endophytic microbiome of rice seeds from conventional and organic farming systems, finding higher bacterial diversity in conventional and fungal diversity in organic systems, with some bacteria showing pathogen inhibition.

Deletion of smooth muscle O-GlcNAc transferase prevents development of atherosclerosis in western diet-fed hyperglycemic ApoE-/- mice in vivo

This study shows that deleting smooth muscle O-GlcNAc transferase (smOGT) reduces atherosclerosis in hyperglycemic ApoE-/- mice fed a Western diet.

The Evolution of Centriole Degradation in Mouse Sperm

This paper investigates how sperm centrioles evolved to become dispensable in mice by analyzing changes in the FAM161A protein and centriole structure across rodent species.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

High-Risk Human Papillomavirus Oncogenes Disrupt the Fanconi Anemia DNA repair Pathway by Impairing Localization and De-ubiquitination of FancD2

This paper shows that HPV oncogenes E6/E7 disrupt the FA DNA repair pathway by impairing FancD2 localization, de-ubiquitination, and downstream protein recruitment, increasing cisplatin sensitivity.