Author

D. A. Holdbrook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

P. J. Bond· 2 shared A. Schmidtchen· 1 shared J. K. Marzinek· 1 shared J. Petrlova· 1 shared J. Yeow· 1 shared K. W. Tan· 1 shared M. Malmsten· 1 shared N. A. Berglund· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

P. J. Bond

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Author profile →

2 papers

Recent·Most cited

Molecular basis for the maintenance of lipid asymmetry in the outer membrane of Escherichia coli

J. Yeow, K. W. Tan, D. A. Holdbrook, Z.-S. Chong, J. K. Marzinek, P. J. Bond, S. S. Chng

The paper defines the molecular architecture of the OmpC-MlaA complex in E. coli and shows how it transports phospholipids across the outer membrane to maintain lipid asymmetry.

bioRxiv · Feb 8, 2018Biochemistry

Structural basis for endotoxin neutralization and anti-inflammatory activity of thrombin-derived C-terminal peptides

R. Saravanan, D. A. Holdbrook, J. Petrlova, S. Singh, N. A. Berglund, Y. K. Choong, P. J. Bond, M. Malmsten, A. Schmidtchen

This paper identifies the structural basis of thrombin-derived C-terminal peptides' ability to neutralize endotoxin and reduce inflammation by interacting with LPS and CD14.

bioRxiv · Dec 12, 2017Biophysics