Author

D. A. Mordes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

D. R. Southworth· 2 shared A. A. Melo· 1 shared A. C. Thwin· 1 shared A. Oehler· 1 shared C. M. Nadel· 1 shared C. S. Craik· 1 shared E. Tse· 1 shared F. Candido· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

D. R. Southworth

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Author profile →

2 papers

Recent·Most cited

Structure of a novel α-synuclein filament fold from multiple system atrophy

N. L. Yan, F. Candido, E. Tse, A. A. Melo, S. B. Prusiner, D. A. Mordes, D. R. Southworth, N. A. Paras, G. E. Merz

The paper determines the structure of a novel α-synuclein filament fold in multiple system atrophy using cryo-EM, identifying a new filament type distinct from other synucleinopathies.

bioRxiv · Jul 1, 2024 · PreprintBiophysics

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP

C. M. Nadel, K. Wucherer, A. Oehler, A. C. Thwin, K. Basu, M. D. Callahan, D. R. Southworth, D. A. Mordes, C. S. Craik, J. E. Gestwicki

This study identifies phosphorylation at residue S416 on tauC3 as a mechanism that inhibits its degradation by CHIP, contributing to its accumulation in Alzheimer's disease.

bioRxiv · Aug 16, 2023 · PreprintBiochemistry