Modification of an atypical clathrin-independent AP-2 adaptin complex of Plasmodium falciparum reduces susceptibility to artemisinin
R. C. Henrici, R. L. Edwards, M. Zoltner, D. A. van Schalkwyk, M. N. Hart, F. Mohring, R. W. Moon, S. D. Nofal, A. Patel, C. Flueck, D. A. Baker, A. Odom John, M. C. Field, C. J. Sutherland
This study shows that modifying the AP-2 adaptin complex in Plasmodium falciparum reduces susceptibility to artemisinin, suggesting alternative mechanisms of drug resistance beyond pfkelch13 mutations.
bioRxiv · Apr 30, 2019 · PreprintMicrobiology