Reconstitution of autophagosomal membrane tethering reveals that Atg11 can bind and cluster vesicles on cargo mimetics
D. Andhare, S. Katzenell, S. I. Najera, K. M. Bauer, M. J. Ragusa
This study shows Atg11 binds autophagosomal-like membranes via an amphipathic helix, clustering vesicles on cargo mimetics to initiate mitophagy.
bioRxiv · Dec 19, 2023 · PreprintBiochemistry