Mechanistic analysis of a novel membrane-interacting variable loop in the pleckstrin-homology domain critical for dynamin function
H. Khurana, S. Bhattacharyya, T. Pucadyil
This study investigates a novel variable loop in the dynamin PHD domain, showing that reduced hydrophobicity impairs membrane fission and CME, linking it to CMT neuropathy.
bioRxiv · Sep 3, 2022Biochemistry