Chemical and structural investigation of the paroxetine-human serotonin transporter complex
J. A. Coleman, V. Navratna, D. Antermite, D. Yang, J. A. Bull, E. Gouaux
The paper investigates the binding of paroxetine and its analogs to the serotonin transporter using structural and biochemical methods, revealing how they stabilize the outward-open conformation and inhibit serotonin transport.
bioRxiv · Feb 26, 2020Biochemistry