β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia
V. Garcia-Hernandez, D. Arambilet, Y. Guillen, T. Lobo, C. Gekas, N. Vega-Garcia, I. Sentis, J. L. Trincado, I. Marquez-Lopez, H. Heyn, M. Camos, L. Espinosa, A. Bigas
The paper identifies a β-catenin-regulated RNA biosynthesis program linked to therapy resistance in T-ALL and suggests combining chemotherapy with β-catenin inhibitors to improve treatment outcomes.
bioRxiv · Jul 7, 2022Cancer Biology