J. L. Trincado

Integrative single-cell multi-omics of CD19CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias

This study integrates single-cell multi-omics data from CAR-T cells to identify factors influencing immunotherapy response in B-cell neoplasias.

β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia

The paper identifies a β-catenin-regulated RNA biosynthesis program linked to therapy resistance in T-ALL and suggests combining chemotherapy with β-catenin inhibitors to improve treatment outcomes.

A comprehensive single-cell expression atlas of human AML leukemia-initiating cells unravels the contribution of HIF pathway and its therapeutic potential

The paper creates a single-cell atlas of AML leukemia-initiating cells and shows that targeting the HIF pathway enhances chemotherapy effectiveness against these cells.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

Combined analysis of genome sequencing and RNA-motifs reveals novel damaging non-coding mutations in human tumors

The paper identifies novel damaging non-coding mutations in human tumors by analyzing genome sequencing and RNA-motifs using a new method called MIRA.