L. Espinosa

Chromatin activity of IκBα mediates the exit from naïve pluripotency

This study shows that IκBα's chromatin activity, not its NF-κB signaling role, is critical for exiting naïve pluripotency in embryonic stem cells.

Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of stem cell and oncogenic programs

This paper identifies IκB's NF-κB-independent role in stem cell and oncogenic programs using separation-of-function mutants.

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

Phage-antibiotic synergy: cell filamentation is a key driver of successful phage predation

This study shows that antibiotic-induced filamentation enhances phage predation by increasing bacterial surface area and susceptibility, leading to phage-antibiotic synergy.

IκBα controls dormancy induction in Hematopoietic stem cell development via retinoic acid

This study shows that IκBα regulates hematopoietic stem cell (HSC) dormancy by controlling retinoic acid signaling during development.

β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia

The paper identifies a β-catenin-regulated RNA biosynthesis program linked to therapy resistance in T-ALL and suggests combining chemotherapy with β-catenin inhibitors to improve treatment outcomes.

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

This study shows that reducing mucin secretion in colorectal cancer cells increases their sensitivity to chemotherapy, offering a strategy to overcome chemoresistance.

Chemotherapy induces a YAP1-dependent fetal conversion to human Colorectal Cancer cells that is predictive of poor patient outcome

The paper shows that sublethal chemotherapy induces a YAP1-dependent fetal phenotype in colorectal cancer cells, which predicts poor patient outcomes.

MiSiC, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities

MiSiC is a deep learning method for segmenting bacterial cells in complex communities, enabling analysis of interspecies interactions with minimal parameter adjustment.

A novel role of MNT as a negative regulator of REL and the NF-κB pathway

This study identifies MNT as a negative regulator of the NF-κB pathway by inhibiting REL translocation and repressing REL-target genes through a MNT-REL complex.

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

The paper identifies FrzB, a divergent CheW in M. xanthus, which lacks the CheA-interacting region and functions upstream of FrzCD to enable distributed chemosensory arrays on the nucleoid, conferring plasticity to chemosensory systems.

The nucleoid as a scaffold for the assembly of bacterial signaling complexes

The paper shows that FrzCD chemoreceptors bind the bacterial nucleoid non-sequence-specifically, forming distributed clusters that enable cooperative signaling.

A gated relaxation oscillator controls morphogenetic movements in bacteria

The paper identifies a gated relaxation oscillator mechanism in Myxococcus xanthus that controls polarity reversals through FrzX and RomR, enabling tunable motility responses.