Author

Y. Guillen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. Bigas· 4 shared L. Espinosa· 4 shared A. Villanueva· 2 shared J. Gonzalez· 2 shared L. Sole· 2 shared M. garrido· 2 shared M. Iglesias· 2 shared M. Martinez-Iniesta· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCancer Biology

A. Bigas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

L. Espinosa, I. Pecharroman Ruiz, L. Sole, D. Alvarez-Villanueva, T. Lobo, J. Alonso, j. Bertran, E. Sabido, E. Borras, V. Garcia-Hernandez, M. garrido, J. Seoane, A. Bigas, A. Villanueva, M. Martinez-Iniesta, , R. salazar

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

IκBα controls dormancy induction in Hematopoietic stem cell development via retinoic acid

R. Thambyrajah, Z. Fadlullah, M. Proffitt, W. H. Neo, Y. Guillen, M. Casado-Pelaez, P. Herrero-Molinero, C. Brujas, N. Castelluccio, J. Gonzalez, A. Iglesias, L. Marruecos, C. Ruiz-Herguido, M. Esteller, E. Mereu, , A. Bigas

This study shows that IκBα regulates hematopoietic stem cell (HSC) dormancy by controlling retinoic acid signaling during development.

bioRxiv · Nov 17, 2022 · PreprintCell Biology

β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia

V. Garcia-Hernandez, D. Arambilet, Y. Guillen, T. Lobo, C. Gekas, N. Vega-Garcia, I. Sentis, J. L. Trincado, I. Marquez-Lopez, H. Heyn, M. Camos, L. Espinosa, A. Bigas

The paper identifies a β-catenin-regulated RNA biosynthesis program linked to therapy resistance in T-ALL and suggests combining chemotherapy with β-catenin inhibitors to improve treatment outcomes.

bioRxiv · Jul 7, 2022Cancer Biology

Gut Microbiome Signatures Linked to HIV-1 Reservoir Size and Viremia Control

A. Borgognone, M. Noguera-Julian, B. Oriol, L. Noël-Romas, M. Ruiz-Riol, Y. Guillen, M. Parera, M. Casadella, C. Duran, M. C. Puertas, F. Catala-Moll, M. De Leon, S. Knodel, K. Birse, C. Manzardo, , R. Paredes

The paper identifies gut microbiome signatures, specifically the Bacteroidales/Clostridiales ratio, associated with HIV-1 reservoir size and viremia control in a clinical trial.

bioRxiv · Oct 3, 2021Immunology

Chemotherapy induces a YAP1-dependent fetal conversion to human Colorectal Cancer cells that is predictive of poor patient outcome

L. Sole, T. Lobo-Jarne, A. Villanueva, A. Vert, Y. Guillen, I. Sangrador, A. Barbachano, J. Lop, M. Guix, M. Salido, B. Bellosillo, R. Garcia-Romero, M. Garrido, J. Gonzalez, M. Martinez-Iniesta, , L. Espinosa

The paper shows that sublethal chemotherapy induces a YAP1-dependent fetal phenotype in colorectal cancer cells, which predicts poor patient outcomes.

bioRxiv · Apr 8, 2021 · PreprintCancer Biology