Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11
D. Mukhopadhyay, D. Arranz-Solis, J. P. Saeij
This study identifies GRA15 and GRA24 as key activators of the innate immune response in Tlr11-/- mice and human cells lacking TLR11/TLR12, showing their role in IL12, IL18, and IL1β secretion and subsequent IFNγ production.
bioRxiv · Feb 14, 2020Immunology