D. Mukhopadhyay

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma

This study shows that SREBP pathway inhibition slows PDAC tumor growth by disrupting lipid homeostasis, suggesting SCAP as a therapeutic target.

RG203KR mutations in SARS-CoV-2 Nucleocapsid: Assessing the impact using Virus-like particle model system

The paper assesses the impact of RG203KR mutation in SARS-CoV-2 nucleocapsid using virus-like particles, showing enhanced immune responses and neutralization.

Growth kinetics and power laws indicate distinct mechanisms of cell-cell interactions in the aggregation process

The paper analyzes the growth kinetics of cellular aggregation under three interaction mechanisms and identifies power law growth and stretched exponential cluster size distributions.

Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases

The paper identifies GRA15 as a Toxoplasma effector that promotes vacuole destruction in IFNγ-activated fibroblasts by recruiting TRAF ubiquitin ligases.

Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11

This study identifies GRA15 and GRA24 as key activators of the innate immune response in Tlr11-/- mice and human cells lacking TLR11/TLR12, showing their role in IL12, IL18, and IL1β secretion and subsequent IFNγ production.

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5

This study identifies NLRP3-dependent but inflammasome-independent pathways regulating CD8 T cell IFNγ responses to Toxoplasma gondii vacuolar antigens, independent of ROP5 virulence factors.