TIN2 facilitates TRF1-mediated trans- and cis-interactions on physiologically relevant long telomeric DNA
H. Pan, P. Kaur, M. Liu, P. Xu, C. Mahn, R. Barnes, Q. Tang, P. Hao, D. Bhattaram, C. You, J. Piehler, K. Weninger, R. Riehn, S. Smith, P. L. Opersko, H. Wang
This study shows TIN2 promotes TRF1-mediated DNA-DNA bridging on telomeres, stabilizing interactions that depend on telomere length and sequence.
bioRxiv · Sep 12, 2020 · PreprintBiophysics