C. You

Long-term single molecule localization microscopy uncovers dynamic co-assembly of Lrp6 and Ror2 into Wnt-signalosomes

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis

This study identifies Arabidopsis AAR2 as a conserved splicing factor that also promotes miRNA biogenesis by interacting with HYL1 and regulating its dephosphorylation.

Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

The paper develops biofunctional nanodot arrays to study Wnt signalodroplets in live cells, revealing synergistic co-condensation through liquid-liquid phase separation.

Parallel analysis of RNA ends reveals global microRNA-mediated target RNA cleavage in maize

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

Physiological and molecular mechanisms regulated mesophyll conductance under severe drought in water-saving drought-resistant rice

This study identifies key genes regulating mesophyll conductance in drought-resistant rice under severe drought by comparing gene expression and photosynthetic processes between two rice cultivars.

Structural insights into the peptide selectivity and activation of human neuromedin U receptors

This study reports cryo-EM structures of NMUR1 and NMUR2 bound to NMU and NMS, revealing peptide selectivity mechanisms and activation principles for drug design.

Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

TIN2 facilitates TRF1-mediated trans- and cis-interactions on physiologically relevant long telomeric DNA

This study shows TIN2 promotes TRF1-mediated DNA-DNA bridging on telomeres, stabilizing interactions that depend on telomere length and sequence.