Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy
M. Xia, M. Varmazyad, I. P. Palacin, D. C. Gavlock, R. Debiasio, G. LaRocca, C. Reese, R. Florentino, L. A. P. Faccioli, J. A. Brown, L. A. Vernetti, M. E. Schurdak, A. M. Stern, A. Gough, J. Behari, , M. Miedel
This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.
bioRxiv · Apr 22, 2024Cell Biology