Author

J. A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. A. Carozza· 2 shared L. Li· 2 shared M. Smith· 2 shared V. Boehnert· 2 shared A. Ananthanarayanan· 1 shared A. Gough· 1 shared A. M. Stern· 1 shared A. R. Savage· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

J. A. Carozza

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy

M. Xia, M. Varmazyad, I. P. Palacin, D. C. Gavlock, R. Debiasio, G. LaRocca, C. Reese, R. Florentino, L. A. P. Faccioli, J. A. Brown, L. A. Vernetti, M. E. Schurdak, A. M. Stern, A. Gough, J. Behari, , M. Miedel

This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.

bioRxiv · Apr 22, 2024Cell Biology

Gut bacteria-derived serotonin promotes immune tolerance in early life

K. Z. Sanidad, S. L. Rager, H. C. Carrow, A. Ananthanarayanan, R. Callaghan, P. Ravisankar, T. Li, A. R. Savage, J. A. Brown, M. Amir, R. Luo, F. Mardorsky Rowdo, M. L. Martin, R. B. Silver, D. Artis, , M. Y. Zeng

This study shows that neonatal gut bacteria produce serotonin, which promotes immune tolerance by inhibiting mTOR and increasing regulatory T cells.

bioRxiv · Sep 25, 2022Immunology

Structure-aided development of small molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP

J. A. Carozza, J. A. Brown, V. Boehnert, D. Fernandez, Y. AlSaif, R. E. Mardjuki, M. Smith, L. Li

This study develops small molecule ENPP1 inhibitors with sub-nanomolar potency and demonstrates their efficacy in delaying tumor growth in a breast cancer model.

bioRxiv · May 30, 2020Biochemistry

Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis

M. A. Marchal, D. Moose, A. Varzavand, D. Taylor, J. A. Brown, M. D. Henry, C. S. Stipp

bioRxiv · May 19, 2020 · PreprintCancer Biology

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry

P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines IL-10 and IL-1β in a human tonsil explant model

A. Y. Soare, N. Durham, R. Gopal, B. Tweel, K. W. Hoffman, J. A. Brown, M. O'Brien, N. Bhardwaj, J. K. Lim, B. K. Chen, T. H. Swartz

bioRxiv · Jul 10, 2018Immunology